Dallas, TX (PRWEB) February 21, 2012
A Panamanian-led, multidisciplinary research team has published the first description of non-expanded fat stem cells in the treatment of rheumatoid arthritis patients. "Autologous Stromal Vascular Fraction Therapy for Rheumatoid Arthritis: Rationale and Clinical Safety", which appears in the January publication of the International Archives of Medicine, followed 13 rheumatoid arthritis patients who were treated with their own fat-derived stem cells.
Treating arthritis with fat-derived stem cells has become commonplace in veterinary medicine over the past five years with over 7,000 horses and dogs treated by publication contributor Vet-Stem, a San Diego-based company. The objective of the joint Panamanian-US study was to determine feasibility of translating Vet-Stem's successful animal results into human patients.
Observing no treatment associated adverse reactions after one year, the team concluded that its protocol should be studied further to determine efficacy in the treatment of rheumatoid arthritis. Their publication details the rationale for the use of fat derived stem cells in treatment of autoimmune conditions and is freely available at: http://www.intarchmed.com/content/pdf/1755-7682-5-5.pdf
“Key to advancement of any medical protocol is transparent disclosure of rationale, treatment procedures and outcomes to the research community in a peer-reviewed and IRB-compliant manner,” said Dr. Jorge Paz Rodriguez, Medical Director of the Stem Cell Institute and research team leader. “While we have previously published case studies on the use of fat stem cells in multiple sclerosis patients, and one rheumatoid arthritis patient, this is the first time that comprehensive follow-up has been completed for a larger cohort of patients,” he added.
An important distinction that separates this particular approach from those which are being explored by several international investigators is that the fat stem cells were not grown in a laboratory, affording a substantially higher level of safety and protocol practicality.
“This work signifies Panama's emergence into the burgeoning field of translational medicine,” commented Dr. Ruben Berrocal Timmons, the Panamanian Secretary of Science and publication co-author. “We are proud to have attracted and collaborated with internationally-renowned stem cell clinical researchers such as Dr. Michael Murphy and Dr. Keith March from the Indiana University School of Medicine Center for Vascular Biology and Medicine, Dr. Boris Minev from the University of California, San Diego Moores Cancer Center, Dr. Chien Shing Chen from Loma Linda University Behavioral Medicine Center and Dr. Bob Harman from Vet-Stem. By leveraging their vast, collective clinical experience with Panamanian scientific infrastructure and know-how, we are striving to develop effective, internationally recognized stem cell procedures that will be accepted the world over.”
The treatment procedure involves a mini-liposuction, collection of the fat's cellular component, processing to obtain a population of cells that includes stem cells, freezing the cells in preparation for quality control, and subsequent re-administration of the cells into patients.
The Panamanian-US group has previously shown that there is a specific type of T cell, called the T regulatory cell, associated with fat stem cells, which is capable of suppressing pathological immunity. Their current theory, which is described in detail in the publication: http://www.ncbi.nlm.nih.gov/pubmed/20537320, is that the T regulatory component of the fat is capable of slowing down or suppressing the “autoimmune” reaction, while the stem cell component causes formation of new tissue to replace the damaged joints.
About the Stem Cell Institute
Founded in 2006 on the principles of providing unbiased, scientifically-sound treatment options, the Stem Cell Institute has matured into the world’s leading adult stem cell therapy and research center. In close collaboration with universities and physicians world-wide, the institute’s doctors treat carefully selected patients with spinal cord injury, osteoarthritis, heart disease, multiple sclerosis, rheumatoid arthritis and other autoimmune diseases. Doctors at The Stem Cell Institute have treated over 1000 patients to-date.
For more information on stem cell therapy:
Stem Cell Institute Web Site: http://www.cellmedicine.com
Facebook: http://www.facebook.com/stemcellinstitute
Blogger: http://www.adult-stem-cell-therapy.blogspot.com
Stem Cell Institute
Via Israel & Calle 66
Pacifica Plaza Office #2A
San Francisco, Panama
Republic of Panama
Phone: +1 800 980-STEM (7836) (USA Toll-free) +1 954 636-3390 (from outside USA)
Fax: +1 866 775-3951 (USA Toll-free) +1 775 887-1194 (from outside USA)
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Showing posts with label stem cells rheumatoid arthritis. Show all posts
Showing posts with label stem cells rheumatoid arthritis. Show all posts
Tuesday, February 21, 2012
Friday, February 17, 2012
Autologous stromal vascular fraction therapy for rheumatoid arthritis: rationale and clinical safety.
Int Arch Med. 2012 Feb 8;5(1):5. [Epub ahead of print]
Paz Rodriguez J, Murphy MP, Hong S, Madrigal M, March KL, Minev B, Harman RJ, Chen CS, Timmons RB, Marleau AM, Riordan NH.
ABSTRACT: Advancements in rheumatoid arthritis (RA) treatment protocols and introduction of targeted biological therapies have markedly improved patient outcomes, despite this, up to 50% of patients still fail to achieve a significant clinical response. In veterinary medicine, stem cell therapy in the form of autologous stromal vascular fraction (SVF) is an accepted therapeutic modality for degenerative conditions with 80% improvement and no serious treatment associated adverse events reported. Clinical translation of SVF therapy relies on confirmation of veterinary findings in targeted patient populations. Here we describe the rationale and preclinical data supporting the use of autologous SVF in treatment of RA, as well as provide 1, 3, 6, and 13 month safety outcomes in 13 RA patients treated with this approach.
PMID: 22313603 [PubMed - as supplied by publisher]
FULL TEXT: http://www.intarchmed.com/content/pdf/1755-7682-5-5.pdf
Paz Rodriguez J, Murphy MP, Hong S, Madrigal M, March KL, Minev B, Harman RJ, Chen CS, Timmons RB, Marleau AM, Riordan NH.
PMID: 22313603 [PubMed - as supplied by publisher]
FULL TEXT: http://www.intarchmed.com/content/pdf/1755-7682-5-5.pdf
Tuesday, February 14, 2012
Stem Cell Therapy for Rheumatoid Arthritis gives patient hope for a pain-free life
The condensed story of my journey to Panama
I was diagnosed with RA in November of 2008. I started with Methotrexate. It made me feel really sick for a couple of months; I adjusted to it somewhat to the extent that I felt queasy for a couple of days after the five or six pills I took every Monday evening.
I still progressively got worse. Then I took Embrel by injection. That only lasted two weeks because I broke out in huge swollen places (looked like red pancakes plastered on my legs where I had taken the injections). Then I tried Areva. That helped some. Only mild nausea, but horrible diarrhea, and the pain worsened.
The right side of my body was affected the worst. I was experiencing difficulty at times holding a fork or a pen. I started taking Celebrex and increased the number of aspirin I was taking daily. Around the first part of 2010 the rheumatologist I was seeing prescribed methotrexate again, but this time in injectable form. The effects were horrible. It was as if I injected myself with food poisoning every Monday evening. I was very sick and unable to work for two days after the shot.
A friend of mine in Corpus Christi, Maryanne Sinclair, contacted me in June and told me the story of a gentleman who had gone to Panama for stem cell therapy. His name is Dusty Durrill. She said the results of the treatment were a miracle for him. He told friends and anyone who would listen about the clinic. My friends said the changes in him were indeed amazing. He was able to walk without assistance, the swelling in his hands and feet had gone down drastically. He flew the head of the clinic to Corpus Christi in June to speak to the people who were wanting more information about the treatments there. I was one of the approximately 200 people who attended the meeting. Dusty Durrell had checked out the clinics in Israel and Germany. There was a clinic at that time also in Costa Rica which has now closed.
I was at that point taking two Celebrex per day and ten to 12 aspirin, and I felt terrible most of time. I applied based on his experience, and arrived in Panama on August 28th.
The following is my testimonial for the Stem Cell Institute
The Stem Cell Institute offers me hope for a pain-free life. I flew to Panama the end of August, 2010 for a two-week stay and treatment for Rheumatoid Arthritis. I was most impressed with their facilities, personnel, and administrative support which are an adjunct to the treatment regimen associated with the patient care. The medical staff exhibits a degree of care which exceeded my expectations. To date, I have experienced positive results from the stem-cell infusions with no adverse reaction. I am continuing to improve which is an apparent result of my treatment.
I am delighted to speak with your prospective patients that want to speak to someone who has been through the Stem Cell Institute.
Sincerely,
Marian D’Unger
I was diagnosed with RA in November of 2008. I started with Methotrexate. It made me feel really sick for a couple of months; I adjusted to it somewhat to the extent that I felt queasy for a couple of days after the five or six pills I took every Monday evening.
The right side of my body was affected the worst. I was experiencing difficulty at times holding a fork or a pen. I started taking Celebrex and increased the number of aspirin I was taking daily. Around the first part of 2010 the rheumatologist I was seeing prescribed methotrexate again, but this time in injectable form. The effects were horrible. It was as if I injected myself with food poisoning every Monday evening. I was very sick and unable to work for two days after the shot.
A friend of mine in Corpus Christi, Maryanne Sinclair, contacted me in June and told me the story of a gentleman who had gone to Panama for stem cell therapy. His name is Dusty Durrill. She said the results of the treatment were a miracle for him. He told friends and anyone who would listen about the clinic. My friends said the changes in him were indeed amazing. He was able to walk without assistance, the swelling in his hands and feet had gone down drastically. He flew the head of the clinic to Corpus Christi in June to speak to the people who were wanting more information about the treatments there. I was one of the approximately 200 people who attended the meeting. Dusty Durrell had checked out the clinics in Israel and Germany. There was a clinic at that time also in Costa Rica which has now closed.
I was at that point taking two Celebrex per day and ten to 12 aspirin, and I felt terrible most of time. I applied based on his experience, and arrived in Panama on August 28th.
The following is my testimonial for the Stem Cell Institute
The Stem Cell Institute offers me hope for a pain-free life. I flew to Panama the end of August, 2010 for a two-week stay and treatment for Rheumatoid Arthritis. I was most impressed with their facilities, personnel, and administrative support which are an adjunct to the treatment regimen associated with the patient care. The medical staff exhibits a degree of care which exceeded my expectations. To date, I have experienced positive results from the stem-cell infusions with no adverse reaction. I am continuing to improve which is an apparent result of my treatment.
I am delighted to speak with your prospective patients that want to speak to someone who has been through the Stem Cell Institute.
Sincerely,
Marian D’Unger
Wednesday, February 1, 2012
Pro/Am Dancer is "Dancing with the Stars" Again After Stem Cell Therapy in Panama
Corpus Christi, TX (PRWEB) February 01, 2012
Pro/Am ballroom dancer and orthodontist, Dr. Janet Vaughan, is once again slated to compete on the professional dance circuit with her current professional partner, Mr. Eddie Stutts (Professional 10-Dance World Champion) following a successful stem cell procedure on her knee in Panama.
From 2007-2009, Dr. Vaughan partnered with World Champion Tony Dovolani and competed extensively in the U.S., winning a National Reserve Pro/Am Rhythm title. Tony Dovolani is best known for his appearances on ABC's hit reality series, "Dancing with the Stars", and has teamed up with Chynna Phillips, Wendy Williams, Audrina Partridge, Kate Gosselin, Kathy Ireland, Susan Lucci, Jane Seymour and other celebrities on the show.
Dr. Vaughan and Mr. Stutts are slated to compete in the Heritage Classic Dancesport Championships in Asheville, North Carolina next month. This will be the first time Dr. Vaughan has been able to compete since 2010 when she sustained a dancing related knee injury.
Dr. Vaughan also suffered from chronic neck pain resulting from injuries sustained in a car crash twenty years ago. Her neck injury culminated in a natural fusion of the c5-c6 vertebrae, scoliosis and extreme pain when her neck slipped out of alignment.
In an attempt to repair her knee and get her dancing career back on track, Dr. Vaughan decided to undergo stem cell therapy at the Stem Cell Institute in Panama City, Panama. "I was basically removed from competitive dance work because I could not rise or squat without extreme pain. I had also resigned myself to enduring chronic neck pain from my past accident and painful hand joints due to generalized arthritis," said Dr. Vaughan.
Dr. Vaughan 's knee was treated with stem cells that were harvested from her own adipose (fat) tissue.
The fat tissue sample is collected via mini-liposuction, which is performed by a certified plastic surgeon under light, general anesthesia. Mesenchymal stem cells and T regulatory cells reside within this tissue.
Adipose-derived cells are then separated from the fat at Medistem Panama’s state-of-the-art laboratory at the prestigious City of Knowledge. This entire process is subjected to stringent quality control. Before they can be administered back into the patient, these adipose-derived stem cells are tested for quality, bacterial contamination (aerobic and anaerobic) and endotoxin.
All patients treated with adipose stem cells at the Stem Cell Institute wait about one week before the stem cells can be re-implanted to minimize the probability of the cells migrating back to the liposuction injury site. This essential procedural step separates treatment in Panama from "same-day" protocols offered elsewhere.
The adipose-derived stem cells are administered by a highly-qualified physician into the affected joint(s) (intra-articular injection) and intravenously (IV).
"It's taken about 6 months but I am amazed at the results I've gotten with my knee. Even my neck is better. I used to spend almost $1,000 per month on a neuromuscular massage therapist but I haven't needed any neuromuscular massages for the past 6 months. I wasn't counting on that. Even my doctors say that the dense scar tissue in my neck has changed in texture from grizzly to smooth, supple tissue," exclaimed Dr. Vaughan.
She continued, "I just danced 6 hours in Houston preparing for the upcoming competition in Asheville and my knee isn't even sore."
Dr. Vaughan is planning to return to Panama for a follow-up treatment this summer.
About the Stem Cell Institute
Founded in 2006 on the principles of providing unbiased, scientifically-sound treatment options, the Stem Cell Institute has matured into the world’s leading adult stem cell therapy and research center. In close collaboration with universities and physicians world-wide, the institute’s doctors treat carefully selected patients with spinal cord injury, osteoarthritis, heart disease, multiple sclerosis, rheumatoid arthritis, and other autoimmune diseases. Doctors at The Stem Cell Institute have treated over 1000 patients to-date.
About Medistem Panama Inc.
Medistem performs all stem cell processing for the Stem Cell Institute. It operates an 8000 sq. ft. cGMP and cGMP compliant laboratory that features 3 class 10000 clean rooms, 8 class 100 laminar flow hoods, and 12 class 100 incubators.
For more information on stem cell therapy:
Stem Cell Institute Website: http://www.cellmedicine.com
Stem Cell Institute
Via Israel & Calle 66
Pacifica Plaza Office #2A
San Francisco, Panama
Republic of Panama
Phone: +1 800 980-STEM (7836) (USA Toll-free) +1 954 636-3390 (from outside USA)
Fax: +1 866 775-3951 (USA Toll-free) +1 775 887-1194 (from outside USA)
Pro/Am ballroom dancer and orthodontist, Dr. Janet Vaughan, is once again slated to compete on the professional dance circuit with her current professional partner, Mr. Eddie Stutts (Professional 10-Dance World Champion) following a successful stem cell procedure on her knee in Panama.
From 2007-2009, Dr. Vaughan partnered with World Champion Tony Dovolani and competed extensively in the U.S., winning a National Reserve Pro/Am Rhythm title. Tony Dovolani is best known for his appearances on ABC's hit reality series, "Dancing with the Stars", and has teamed up with Chynna Phillips, Wendy Williams, Audrina Partridge, Kate Gosselin, Kathy Ireland, Susan Lucci, Jane Seymour and other celebrities on the show.
Dr. Vaughan and Mr. Stutts are slated to compete in the Heritage Classic Dancesport Championships in Asheville, North Carolina next month. This will be the first time Dr. Vaughan has been able to compete since 2010 when she sustained a dancing related knee injury.
Dr. Vaughan also suffered from chronic neck pain resulting from injuries sustained in a car crash twenty years ago. Her neck injury culminated in a natural fusion of the c5-c6 vertebrae, scoliosis and extreme pain when her neck slipped out of alignment.
In an attempt to repair her knee and get her dancing career back on track, Dr. Vaughan decided to undergo stem cell therapy at the Stem Cell Institute in Panama City, Panama. "I was basically removed from competitive dance work because I could not rise or squat without extreme pain. I had also resigned myself to enduring chronic neck pain from my past accident and painful hand joints due to generalized arthritis," said Dr. Vaughan.
Dr. Vaughan 's knee was treated with stem cells that were harvested from her own adipose (fat) tissue.
The fat tissue sample is collected via mini-liposuction, which is performed by a certified plastic surgeon under light, general anesthesia. Mesenchymal stem cells and T regulatory cells reside within this tissue.
Adipose-derived cells are then separated from the fat at Medistem Panama’s state-of-the-art laboratory at the prestigious City of Knowledge. This entire process is subjected to stringent quality control. Before they can be administered back into the patient, these adipose-derived stem cells are tested for quality, bacterial contamination (aerobic and anaerobic) and endotoxin.
All patients treated with adipose stem cells at the Stem Cell Institute wait about one week before the stem cells can be re-implanted to minimize the probability of the cells migrating back to the liposuction injury site. This essential procedural step separates treatment in Panama from "same-day" protocols offered elsewhere.
The adipose-derived stem cells are administered by a highly-qualified physician into the affected joint(s) (intra-articular injection) and intravenously (IV).
"It's taken about 6 months but I am amazed at the results I've gotten with my knee. Even my neck is better. I used to spend almost $1,000 per month on a neuromuscular massage therapist but I haven't needed any neuromuscular massages for the past 6 months. I wasn't counting on that. Even my doctors say that the dense scar tissue in my neck has changed in texture from grizzly to smooth, supple tissue," exclaimed Dr. Vaughan.
She continued, "I just danced 6 hours in Houston preparing for the upcoming competition in Asheville and my knee isn't even sore."
Dr. Vaughan is planning to return to Panama for a follow-up treatment this summer.
About the Stem Cell Institute
Founded in 2006 on the principles of providing unbiased, scientifically-sound treatment options, the Stem Cell Institute has matured into the world’s leading adult stem cell therapy and research center. In close collaboration with universities and physicians world-wide, the institute’s doctors treat carefully selected patients with spinal cord injury, osteoarthritis, heart disease, multiple sclerosis, rheumatoid arthritis, and other autoimmune diseases. Doctors at The Stem Cell Institute have treated over 1000 patients to-date.
About Medistem Panama Inc.
Medistem performs all stem cell processing for the Stem Cell Institute. It operates an 8000 sq. ft. cGMP and cGMP compliant laboratory that features 3 class 10000 clean rooms, 8 class 100 laminar flow hoods, and 12 class 100 incubators.
For more information on stem cell therapy:
Stem Cell Institute Website: http://www.cellmedicine.com
Stem Cell Institute
Via Israel & Calle 66
Pacifica Plaza Office #2A
San Francisco, Panama
Republic of Panama
Phone: +1 800 980-STEM (7836) (USA Toll-free) +1 954 636-3390 (from outside USA)
Fax: +1 866 775-3951 (USA Toll-free) +1 775 887-1194 (from outside USA)
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